Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes

Citation:

K. Sharabi, Lecuona, E. , Helenius, I. T. , Beitel, G. J. , Sznajder, J. I. , and Gruenbaum, Y. . 2009. “Sensing, Physiological Effects And Molecular Response To Elevated Co2 Levels In Eukaryotes”. J Cell Mol Med, 13, Pp. 4304-18.

Abstract:

Carbon dioxide (CO(2)) is an important gaseous molecule that maintains biosphere homeostasis and is an important cellular signalling molecule in all organisms. The transport of CO(2) through membranes has fundamental roles in most basic aspects of life in both plants and animals. There is a growing interest in understanding how CO(2) is transported into cells, how it is sensed by neurons and other cell types and in understanding the physiological and molecular consequences of elevated CO(2) levels (hypercapnia) at the cell and organism levels. Human pulmonary diseases and model organisms such as fungi, C. elegans, Drosophila and mice have been proven to be important in understanding of the mechanisms of CO(2) sensing and response.

Notes:

Sharabi, KfirLecuona, EmiliaHelenius, Iiro TaneliBeitel, Greg JSznajder, Jacob IashaGruenbaum, YosefengR01 GM069540/GM/NIGMS NIH HHS/R01 HL085534/HL/NHLBI NIH HHS/GM069540/GM/NIGMS NIH HHS/HL085534/HL/NHLBI NIH HHS/Research Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReviewEnglandJ Cell Mol Med. 2009 Nov-Dec;13(11-12):4304-18. doi: 10.1111/j.1582-4934.2009.00952.x. Epub 2009 Oct 23.